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This assay is used for evaluation of patients with suspected Sarcoidosis. ACE activity reflects the severity of Sarcoidosis showing 68% positivity in stage I of the disease, 86% in stage II and 91% in stage III. There is a marked decrease in ACE activity in patients of Sarcoidosis on Prednisone therapy. It may also be increased in Gaucher disease, Leprosy, Psoriasis, Amyloidosis and Histoplasmosis.
Overnight fasting is preferred.