LEBERS HEREDITARY OPTIC NEUROPATHY (LHON)

Overview

Lebers Hereditary Optic Neuropathy (LHON) is a mitochondrial disorder leading to severe visual impairment or even blindness. There is destruction of retinal ganglion cells due to mutation of the mitochondrial genome. It usually manifests in 2nd or 3rd decade of life and can involve both eyes with time delay of some months. Males are affected more than females.