YO ANTIBODY (NEURONAL ANTIBODY FOR PARANEOPLASTIC) SYNDROMES (O.S.)

Overview

Purkinje cells cytoplasmic antibody (Yo) can be found in approximately 50% of patients with paraneoplastic cerebellar degeneration (PCD). The presence of Yo antibody strongly suggests underlying gynecological cancer primarily of ovarian or breast origin. A negative assay for Yo antibody does not exclude the possibility of a malignant tumor.