A FISH test looks for a small number of specific changes in genes or chromosomes in the chronic lymphocytic leukaemia (CLL) cells. It gives information about the gene changes in chromosomes, such as whether a part is missing or deleted. Information from these tests helps doctors know how well certain drugs may work. This helps them plan your treatment. A blood sample is used for a FISH test for CLL. Tests that look at changes in genes or chromosomes are called cytogenetic tests.CLL with a p53 deletion or p53 mutation does not usually respond well to standard chemotherapy treatment. Doctors use different types of drugs, called targeted therapy drugs, to treat this type of CLL.
Give brief clinical history.
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