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Test
test details

TPMT ENZYME ACTIVITY (O.S)

MRP: ₹4200

Recommended For

maleMalefemaleFemale
  • Age Group
    Age Group0-99 Years
  • Report Generation Time
    Report Generation Time02-06-2024 08:12:31
  • Sample Type
    blood samplePlasma
  • Collection At
    home visitHomelab flaskLab
Description

Thiopurine methyltransferase (TPMT) deficiency is a condition in which patients treated with standard doses of azathioprine (AZA, Imuran), 6-mercaptopurine (6-MP, Purinethol), or 6-thioguanine (6-TG, Thioguanine Tabloid) may develop life-threatening myelosuppression or severe hematopoietic toxicity. Detection of individuals with low thiopurine methyltransferase (TPMT) activity who are at risk for excessive myelosuppression or severe hematopoietic toxicity when taking thiopurine drugs. Detection of individuals with hyperactive TPMT activity who have therapeutic resistance to thiopurine drugs and may develop hepatotoxicity if treated with these drugs. Ref. value: 3.00-6.66 nmol/mL/hour 6-Methylmercaptopurine (normal) 5.04-9.57 nmol/mL/hour 6-Methylmercaptopurine riboside (normal) 2.70-5.84 nmol/mL/hour 6-Methylthioguanine riboside (normal)

Pre-Information

Duly filled Genomics Clinical Information Requisition Form is mandatory.

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