VITAMIN B-12 ACTIVE

Requirements

Sample Required Serum
Preperations Required No specific preparation required. To protect from light, wrap with aluminium foil. 24 hours before sample collection.
Gender Male & Female
Age Group 0 - 70000 Years
Collection AtHome & Lab

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VITAMIN B-12 ACTIVE

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Overview

Vitamin B12 in plasma binds to two proteins: transcobalamin (active, cell-available) and haptocorrin (inactive). Measuring holo-transcobalamin (holoTC) is thus more clinically relevant than total B12. Deficiency is also indicated by elevated homocysteine (tHcy) and methylmalonic acid (MMA) levels, as both accumulate when cellular B12 is low.