Herpes simplex virus (HSV), i.e. HSV-1 & HSV-2 causes various genital & non-genital syndromes. Sites involved include skin, lips, oral cavity, eYES, genital tract & central nervous system (CNS). Systemic involvement may also occur. HSV-1 infections usually involve non-genital areas and HSV-2 infections are primarily found in genital areas, but there is overlap between the two types. HSV PCR detection is a sensitive and specific method for detection of the disease in oral, genital, ocular, CNS and other sites.