Overview
This major histocompatibility coded class I antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium.There is an increased prevalence of HLA-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.
What is the HLa B27 Test ?
This major histocompatibility coded class I Antigen is associated with Ankylosing Spondylitis, Juvenile Rheumatoid Arthritis, and Reiter Syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium.There is an increased prevalence of HLA-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.
What is the Purpose of the HLa B27 Test ?
An HLa B27 Test is generally advised in several circumstances, which are:
- Chronic Back Pain or Stiffness: When symptoms suggest ankylosing spondylitis or other inflammatory back conditions.
- Joint Pain and Swelling: To evaluate for conditions like reactive arthritis or psoriatic arthritis.
- Eye Inflammation: In cases of recurrent or chronic uveitis, often linked to autoimmune disorders.
- Family History of Autoimmune Diseases: If close relatives have HLA-B27-associated conditions, especially with similar symptoms.
- Unexplained Inflammatory Symptoms: When inflammation in the body persists without a clear cause, autoimmune diseases are suspected.
When is an HLa B27 Test Recommended ?
If you have following symptoms or conditions, then HLa B27 Test is advised:
- Persistent back pain or stiffness that worsens in the morning or improves with exercise
- Joint swelling or pain linked to reactive arthritis, psoriatic arthritis, or other inflammatory joint conditions.
- Eye redness, pain, or sensitivity to light associated with recurrent or chronic uveitis, commonly associated with autoimmune diseases
- Skin or nail changes such as psoriasis or thickened, discolored nails, which may indicate psoriatic arthritis.
- Family history of autoimmune disorders
- Unexplained chronic inflammation
Preparation for HLa B27 Test
There is no special preparation required before the HLa B27 Test.
- Other blood tests can be carried out in addition to an HLa B27 Test. If your doctor advises you to have multiple tests at once, they may ask you to fast for a specific period of time prior to a blood test.
- Drink adequate water before sample collection.
- Follow the preparatory instructions as guided by your doctor.
What is the Cost of an HLa B27 Test ?
The Price of an HLa B27 Test is Rs. 2100. However, cost of the test may fluctuate depending on following factors:
- Other tests advised along with HLa B27 Test
- Offers or discounts
- Empanelment of the patient
Components of HLa B27 Test
- HLa B27: A particular Protein called HLA-B27, also known as human Leukocyte Antigen or HLA, is present on the surface of Cells. Also, the Gene that codes for the HLA-B27 Protein is referred to as HLA-B27. The body's immune system uses human Leukocyte Antigens, which are Proteins, to recognise its own cells and differentiate between "Self" and "Nonself."
Interpreting the HLa B27 Test Results
HLA-B27 is present if the test is positive. It implies an elevated risk for the onset or presence of specific autoimmune diseases. When healthy body tissue is mistakenly attacked and destroyed by the immune system, it can lead to an autoimmune illness. A positive test can assist your doctor in diagnosing spondyloarthritis, a kind of Arthritis. This type of Arthritis encompasses the following conditions:
- Ankylosing spondylitis
- Arthritis related to Crohn disease or ulcerative colitis
- Psoriatic arthritis (arthritis associated with psoriasis)
- Reactive arthritis
- Sacroiliitis (inflammation of the sacroiliac joint)
- Uveitis
How is the HLa B27 Test Done ?
The Blood Sample for HLa B27 Test is taken in following steps:
- The area where the Needle will be inserted to take your blood is cleaned with an Antiseptic Alcohol wipe. The hollow on the inside side of the Elbow or the tip of the Finger are the most common sites for this.
- A tourniquet or a Band is tied around your upper Arm to facilitate the access to the Vein in your Arm.
- A Needle is used to puncture your Vein. The Blood sample is collected into a test tube attached to the Needle. The Needle may cause a small pinch or sting when it is inserted.
- Once the Vial or test tube is filled, the Blood sample collection for the test is finished and the Needle is taken out.
- Finger pressure is applied on the puncture site to stop the bleeding and the band aid is applied at the site.
How to Schedule an HLa B27 Test with Dr. B. Lal Lab ?
- Go to the Dr. B. Lal Lab website.
- Go to the “Book a test” tab.
- Select the “Lab Test” tab.
- Type “HLa B27 Test” in the search bar.
- Click on the test.
- The test page with all the test details will show up.
- Click on “Book Now”.
- Login and verify your mobile number with OTP.
- Now enter your details.
- Select date & time for booking HLa B27 Test in Jaipur.
- Check out.
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