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Myasthenia gravis (MG) is characterised by muscle weakness & easy fatigability most commonly due to autoantibody mediated loss of functional acetylcholine receptors. ACHR antibodies are not found in Congenital MG. This assay is used to diagnose Acquired forms of MG (90% positive), for detecting subclinical MG in recipients of D-penicillamine, Thymoma without clinical evidence of MG & Graft versus Host disease. It may also be positive in Lambert-Eaton myasthenic syndrome, Autoimmune liver disease & Paraneoplastic autoimmune neurological disorders.
Avoid general anaesthetic or muscle relaxant drugs 24 hours prior to sampling. This assay should not be requested for patients who have recently received radio-isotopes therapeutically or diagnostically due to potential assay interference.