Common ragweed (Ambrosia artemisiifolia) is an aggressive plant with its origin most probably from the regions of Northern America. Allergic rhinitis (AR) due to hypersensitivity reaction to inhaled ragweed allergens, is a prevalent medical problem in all age groups including children, adolescents and adults. Allergen-specific immunotherapy (AIT), symptomatic medications and allergen avoidance are the main strategies for the prevention and treatment of allergic rhinitis and asthma due to A. artemisiifolia. Significant cross-reactivity exists between common ragweed and mugwort, marshelder or other grass pollens.