RENIN DIRECT (PLASMA) O.S.

Requirements

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    Sample Required EDTA Blood

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    Preperations Required 3 ml of EDTA plasma to be sent in the aliquot tube at -20°C. Record the time of day and patient's posture during blood collection. (Supine Upright or seated). Labile Analyte. High Biotin dose(>5 mg/day)should be avoided at least 8 hrs before to blood collection.

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    Gender Male & Female

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    Age Group 0 - 70000 Years

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    Collection AtHome & Lab

3300
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    1 Observations included

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RENIN DIRECT (PLASMA) O.S.

Observations Included

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Overview

The renal juxtaglomerular apparatus generates renin, an enzyme that converts angiotensinogen to angiotensin I. The inactive angiotensin I is enzymatically converted to the active octapeptide angiotensin II, a potent vasopressor responsible for hypertension of renal origin. Angiotensin II also stimulates the zona glomerulosa of the adrenal cortex to release aldosterone. Renin secretion by the kidney is stimulated by a fall in glomerular blood pressure, by decreased sodium concentration at the macula densa at the distal tubule, or by stimulation of sympathetic outflow to the kidney, such as in renal vascular diseases. Kidney disease, such as unilateral renal artery stenosis, results in elevated renin and aldosterone levels. Kidney venous catheterization may be helpful. A positive test is a renal venous renin ratio (affected:normal) above 1.5.

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