Overview
Celiac disease is associated with a variety of autoantibodies, including endomysial, tissue transglutaminase (tTG), and deamidated gliadin antibodies. Although the IgA isotype of these antibodies usually predominates in celiac disease, individuals may also produce IgG isotypes, particularly if the individual is IgA deficient. The most sensitive and specific serologic tests are tTG and deamidated gliadin antibodies. The disease is HLA-associated (>95% of patients have DQ2 & DQ8 HLA marker) and manifests at any age with a peak onset in early childhood, even in neonates. The determination of IgG antibodies to tTG is the only available specific serology for those 2% to 5% of patients with IgA deficiency.
What is Ttg-iga ?
Celiac Disease is associated with a variety of autoantibodies, including Endomysial, Tissue Transglutaminase (tTG), and deamidated gliadin antibodies. Although the IgA isotype of these antibodies usually predominates in celiac disease, individuals may also produce IgG isotypes, particularly if the individual is IgA deficient. The most sensitive and specific serologic tests are tTG and deamidated gliadin antibodies. The disease is HLA-associated (>95% of patients have DQ2 & DQ8 HLA markers) and manifests at any age with a peak onset in early childhood, even in neonates. The determination of IgG antibodies to tTG is the only available specific serology for those 2% to 5% of patients with IgA deficiency.
What is the Cost of Ttg-iga
The Price of a TTG-IgA Test is Rs. 120. However, cost of the Test may fluctuate depending on following factors:
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Other tests advised along with TTG-IgA Test
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Offers or discounts
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Empanelment of the patient
What is the Purpose of the Ttg-iga ?
The main purpose of celiac disease antibody testing is to assist in the diagnosis and follow-up of celiac disease in individuals exhibiting symptoms such as anemia and abdominal pain. Approximately 4% to 12% of people have or will acquire celiac disease, hence screening for the condition in asymptomatic family members may sometimes be done using coeliac testing. This testing may also be advised for those who have other autoimmune diseases.
When is the Ttg-iga Recommended ?
TTG-IgA Test is advised if you are suffering from following symptoms:
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Abdominal pain & distension
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Blood in stools
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Chronic diarrhea
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Constipation
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Flatulence
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Greasy, foul-smelling stools
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Vomiting
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Nausea
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Lactose intolerance
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Iron-deficiency anemia that is unresponsive to iron supplements
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Easy bruising and/or bleeding
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Bone and joint pain
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Defects in dental enamel
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Fatigue
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Weakness
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Mouth ulcers
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Weight loss
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Infertility
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Osteoporosis
In children, this test may be advised when a child exhibits:
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Digestive tract symptoms
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Short stature
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Delayed development
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Failure to thrive
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Weight loss
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Permanent damage to tooth enamel
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Mood changes
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Anxiety
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Impatience
Preparation for Ttg-iga
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Unless otherwise directed by your doctor, there is no need for you to make any special preparations before the TTG-IgA Test.
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Other blood tests can be carried out in addition to this test. If your doctor advises you to have multiple tests at once, they may ask you to fast for a specific period of time prior to a blood test.
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Drink adequate water before sample collection.
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Follow the preparatory instructions as guided by your doctor.
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