SS-A/Ro is an extractable nuclear antigen with antibodies occuring in patients with Sjogrens syndrome (90%), Lupus erythematosus (40-60%) & Rheumatoid arthritis. Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive. A positive result for SS-A/Ro antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis