ANTI THROMBIN- III ANTIGEN (O.S.)

Requirements

Sample Required SODIUM CITRATE PLASMA
Preperations Required Overnight fasting is preferred. Patient should avoid Anabolic steroids, Gemfibrozil, Heparin therapy, Asparaginase, Estrogens, Gestodene and Oral contraceptives 3 days prior to specimen collection. Duly filled Coagulation Requisition Form & Test send Out. Clinical History is mandatory
Gender Male & Female
Age Group 0 - 99 Years
Collection AtHome & Lab

₹ 5000

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ANTI THROMBIN- III ANTIGEN (O.S.)

Observations Included

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Overview

Antithrombin is a member of the serine protease inhibitor (serpin) superfamily. It is the principal plasma anticoagulant serpin mediating inactivation of serine protease procoagulant enzymes, chiefly thrombin and coagulation factors Xa and IXa.(1) Heparin and certain other naturally occurring glycosaminoglycans markedly enhance antithrombins anticoagulant activity (approximately 1,000-fold) by providing a template to catalyze formation of covalently bonded, inactive complexes of serine protease and antithrombin that are subsequently cleared from circulation. Antithrombin is the mediator of heparins anticoagulant activity. 6 mL Whole blood in 2 Blue Top (Sodium Citrate) tube. Mix thoroughly by inversion. Transport to the Lab within 4 hours. If this is not possible, prepare PPP within 1 hour of collection as follows: Prepare PPP within 1 hour of collection as follows: Centrifuge sample at 3600 rpm for 15 min. & transfer supernatant to a clean plastic tube. Centrifuge this supernatant again at 3600 rpm for 15 mins. & finally transfer the supernatant (PPP) to 1 labelled, clean plastic screw capped vial. FREEZE IMMEDIATELY. Ship frozen. DO NOT THAW.