A FISH test looks for a small number of specific changes in genes or chromosomes in the chronic lymphocytic leukaemia (CLL) cells. It gives information about the gene changes in chromosomes, such as whether a part is missing or deleted. Information from these tests helps doctors know how well certain drugs may work. This helps them plan your treatment. A blood sample is used for a FISH test for CLL. Tests that look at changes in genes or chromosomes are called cytogenetic tests.CLL with a p53 deletion or p53 mutation does not usually respond well to standard chemotherapy treatment. Doctors use different types of drugs, called targeted therapy drugs, to treat this type of CLL.