Some hemoglobin disorders can be very complex and involve abnormalities of the alpha, beta, delta, and gamma genes. These abnormalities can be due not only to point variants but also to deletions within one or more globin genes. Multiple genetic variants can be seen in the same patient, and molecular testing is necessary to fully evaluate such cases. A summary interpretation that incorporates all of the testing performed is beneficial to the ordering physician for making an accurate diagnosis and developing an appropriate treatment plan.