This assay is useful in monitoring whole blood Tarcolimus concentration during therapy particularly in individuals co-administered CYP3A4 substrates, inhibitors or inducers. It helps to evaluate patient compliance and adjust dose while minimizing toxicity.Since 90% of tacrolimus is in the cellular components of blood, especially erythrocytes, whole blood is the preferred specimen for analysis of trough concentrations.Optimal trough blood concentrations are generally between 5.0 and 15.0 ng/mL. Higher levels are often sought immediately after transplant, but as organ function stabilizes at about 4 weeks from transplant, doses are generally reduced in stable patients for most solid organ transplants. Trough concentrations should be maintained below 20 ng/mL.
Please provide clinical history, the history of the medicine dose taken, the moment the sample was collected (peak or trough levels, for example C0 or C2), and the sample itself.
Download the free health test app from Dr. B. Lal Clinical Laboratory. Find all the healthcare information and needs you require in just one place. You can schedule home collection, see reports, save medical history, search for more than 1800 tests, and more with just one app. Available both on iOS and Android. Simplify healthcare, download the Dr. B. Lal Clinical Lab App.