Low IGFBP-3 levels are observed in Growth hormone (GH) deficiency / resistance. Elevated levels indicate a sustained overproduction of GH or excessive recombinant human Growth hormone (rhGH) injections. This assay is useful for diagnosing growth disorders and adult GH deficiency. It is also used to monitor rhGH treatment. This test can also be used as an adjunct to IGF-1 & GH in the diagnosis and followup of Acromegaly & Gigantism.