c-ANCA(PR3) & p-ANCA (MPO) BY EIA

Overview

Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with small blood vessel vasculitis including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), or eosinophilic granulomatosis with polyangiitis (EGPA), collectively referred to as ANCA-associated vasculitis (AAV). The pANCA pattern may also be observed in patients with inflammatory bowel disease, predominantly ulcerative colitis, usually in the absence of detectable MPO-ANCA reactivity. Positive results for antineutrophil cytoplasmic antibodies (ANCA) demonstrate two main patterns namely; cytoplasmic (cANCA) and perinuclear (pANCA) in a compendium of small vessel vasculitis collectively referred to as ANCA-associated vasculitis (AAV) that includes granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis