Globally, grass pollens are a significant cause of IgE-mediated allergy, affecting approximately 40% of all grass allergic patients. The pollinating season of cultivated rye varies between May and August, differing according to the geographical location. Its pollens are shed in huge amounts and are considered as a significant triggering factor for acute allergic symptoms like conjunctivitis, allergic rhinitis, and asthma in individuals sensitized to grass pollens. Sensitization to pollens of cereals is widespread. Cultivated rye shows extensive cross-reactivity with the other species of Pooideae family including Timothy grass and perennial ryegrass.