Estrogen receptor (ER), progesterone receptor (PR), and c-ERBB2 (HER2/neu) are therapeutically and prognostically important markers in the management of breast carcinoma. They are not always analyzed in distant metastatic and locally recurrent breast cancers. E-CADHERIN IHC is generally negative in Lobular carcinoma, which helps differentiate it from ductal carcinoma where E-CADHERIN is typically positive.