PROTHROMBIN (FACTOR II) MUTATION

Overview

The Prothrombin (Factor II) gene 20210G>A mutation is associated with elevated prothrombin. Higher concentrations of prothrombin lead to increased rates of thrombin generation, resulting in excessive growth of fibrin clots. Heterozygosity for 20210G>A is associated with a 3-fold increased risk of venous thrombosis. Affected individuals may be candidates for antithrombotic prophylaxis.