Preperations Required Note time of day and position of patient (supine or upright). Mention treatment history of spironolactone or ACE inhibitors.Labile analyte.Separate At The Earliest. Patient should be ambulatory / upright 2 hours prior to the test. Separate plasma and freeze. Ship frozen. DO NOT THAW. Drug interactions to be noted: Potassium wasting diuretics, Spironolactone, Eplerenone, Amiloride and Triamterene should be discontinued at least for 4 weeks; Adrenergic blockers, Clonidine, Methyldopa, NSAIDs, Angiotensin-converting enzyme inhibitors, Angiotensin receptor blockers, Renin inhibitors and Dihydropyridine calcium channel antagonists should be discontinued for 2 weeks. If necessary to maintain hypertension control, patients should be treated with other antihypertensive medications like Verapamil slow-release, Hydralazine, Prazosin, Doxazosin & Terazosin that have lesser effects on Plasma renin & aldosterone levels. Any change in medication should be done in consultation with treating physician.
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ALDOSTERONE-RENIN RATIO (O.S.)
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Overview
This ratio can be used as a screening test in cases of severe hypertension. The ratio allows detection of cases of Primary Aldosteronism in normokalemic patients