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Valproic Acid is used for the treatment of simple and complex absence seizures and in combination with other anti-convulsants for treatment of generalized seizures. This assay is useful for monitoring therapy, assessing compliance and evaluating potential toxic effects.Hepatic failure and a Reyes-like syndrome associated with administration of valproic acid at therapeutic levels have been reported. Careful monitoring of liver function during the first 6 months of therapy is required.
Recommended specimen: just before the next dose is due at steady state.